Looks like something has gone wrong with the update.
Can you check your Help > About > Installation Details > Installed software list and push a snapshot here?
Sounds like one of the feature (EBS Target Binding, the component which manages Run/Debug configurations) has not been updated correctly (still in 2.2.1)…
Please give a try to update it manually: go to Help > Install New Software and select only the Target Binding feature.