Forgot to mention that I have an external pull-up of 10K to 2V8 of the WISMO228 before the TXB0104 translator.
It has been working with this pull-up all the while.
I also know that there’s an internal pull-up of 10K on the RI line.
So, the overall pull-up is 5K.
But, I just got it working again if I remove the external 10K pull-up and replace it with a either a 1K or 5K1 resistor which brings the total pull-up resistance to 0.9K and 3.37K (not very far from the default 5K case?).
So, I can only assume that the RI drive capability is very low?